Organization and dynamics of AMPA receptors inside synapses-nano-organization of AMPA receptors and main synaptic scaffolding proteins revealed by super-resolution imaging

Curr Opin Chem Biol. 2014 Jun:20:120-6. doi: 10.1016/j.cbpa.2014.05.017. Epub 2014 Jun 27.


Progresses in microscopy have often led to major discoveries in neuroscience, and the recent advent of super-resolution microscopy is no exception. In this review, we will show how imaging has advanced our modern vision of synaptic function. More particularly, we will emphasize how novel nanoscopy techniques have helped in deciphering the organization of post-synaptic proteins, offering new insight into the mechanism of synaptic transmission.

Publication types

  • Review

MeSH terms

  • Animals
  • Intracellular Signaling Peptides and Proteins / metabolism
  • Protein Binding
  • Protein Transport
  • Receptors, AMPA / metabolism*
  • Synapses / metabolism*
  • Synaptic Transmission


  • Intracellular Signaling Peptides and Proteins
  • Receptors, AMPA