Detection of nonpolypoid colorectal neoplasia using magnifying endoscopy in colonic inflammatory bowel disease

Gastrointest Endosc Clin N Am. 2014 Jul;24(3):405-17. doi: 10.1016/j.giec.2014.03.011.


Patients with inflammatory bowel diseases (IBD) have a high risk of colitis-associated dysplasia and cancer. It is important that careful surveillance with colonoscopy is performed for all patients with IBD and, more frequently, for those considered to be at high risk. Traditionally, flat dysplasia in ulcerative colitis has been considered to be detectable only by using random biopsy specimens of mucosa that appeared unremarkable during endoscopy. However, recent studies have shown that most of them are visible; thus, their detection as nonpolypoid colorectal neoplasms is an integral component in the prevention of colitic cancer.

Keywords: Autofluorescence imaging; Colitis-associated dysplasia/cancer; Image-enhanced endoscopy; Inflammatory bowel disease; Magnifying endoscopy; Narrow band imaging; Ulcerative colitis.

Publication types

  • Review

MeSH terms

  • Adenocarcinoma / diagnosis
  • Adenocarcinoma / etiology
  • Adenocarcinoma / pathology*
  • Colon / pathology*
  • Colonoscopy / methods*
  • Colorectal Neoplasms / diagnosis
  • Colorectal Neoplasms / etiology
  • Colorectal Neoplasms / pathology*
  • Coloring Agents
  • Humans
  • Image Enhancement / methods*
  • Indigo Carmine
  • Inflammatory Bowel Diseases / complications
  • Inflammatory Bowel Diseases / pathology*
  • Narrow Band Imaging / methods


  • Coloring Agents
  • Indigo Carmine