Five polyostotic conditions that general orthopedic surgeons should recognize (or should not miss)

Orthop Clin North Am. 2014 Jul;45(3):417-29. doi: 10.1016/j.ocl.2014.04.004.

Abstract

General orthopedic surgeons frequently encounter patients with conditions affecting multiple bones. It is important to recognize common polyostotic diseases. This article describes five polyostotic conditions: Multipe Enchondromatosis (Ollier Disease and Maffucci syndrome), Multiple Hereditary Exostosis (Diaphyseal Aclasis), Fibrous Dysplasia (McCune-Albright syndrome and Mazabraud syndrome), Paget's Disease of bone (Osteitis Deformans), and Skeletal Metastases. This is a survey of the clinical, pathologic and radiographic features that assist in diagnosing these conditions. Also, an overview of the laboratory findings, treatment, follow-up, and prognosis is presented. Recognizing these diseases will aid in prompt and accurate diagnosis and appropriate referral and therapy.

Keywords: Fibrous dysplasia; Maffucci syndrome; Multiple exostosis; Ollier disease; Paget disease; Polyostotic; Skeletal metastases.

Publication types

  • Review

MeSH terms

  • Bone Neoplasms / diagnosis*
  • Bone Neoplasms / secondary
  • Bone Neoplasms / surgery
  • Calcinosis / diagnostic imaging
  • Enchondromatosis / diagnosis*
  • Enchondromatosis / surgery
  • Exostoses, Multiple Hereditary / diagnosis*
  • Exostoses, Multiple Hereditary / surgery
  • Femur / diagnostic imaging
  • Fibrous Dysplasia of Bone / diagnosis*
  • Humans
  • Magnetic Resonance Imaging
  • Osteitis Deformans / diagnosis*
  • Osteitis Deformans / surgery
  • Prognosis
  • Tibia / diagnostic imaging
  • Tomography, X-Ray Computed