Enhanced infrared neural stimulation using localized surface plasmon resonance of gold nanorods

Small. 2014 Oct 15;10(19):3853-7. doi: 10.1002/smll.201400599. Epub 2014 Jun 27.


An advanced optical activation of neural tissues is demonstrated using pulsed infrared light and plasmonic gold nanorods. Photothermal effect localized in plasma membrane triggers action potentials of in vivo neural tissues. Compared with conventional infrared stimulation, the suggested method can increase a neural responsivity and lower a threshold stimulation level significantly, thereby reducing a requisite radiant exposure and the concern of tissue damage.

Keywords: gold nanoparticles; infrared neural stimulation; photothermal effect; surface plasmon resonance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials
  • Animals
  • Cell Membrane / metabolism
  • Gold / chemistry*
  • Lasers
  • Male
  • Metal Nanoparticles / chemistry*
  • Microscopy, Electron, Transmission
  • Nanotechnology
  • Nanotubes / chemistry*
  • Neurons / metabolism
  • Neurons / pathology*
  • Optics and Photonics
  • Photochemistry
  • Rats
  • Rats, Sprague-Dawley
  • Spectrophotometry, Infrared
  • Surface Plasmon Resonance


  • Gold