Invasive hemodynamic characterization of heart failure with preserved ejection fraction

Heart Fail Clin. 2014 Jul;10(3):435-44. doi: 10.1016/j.hfc.2014.03.001.


Recent hemodynamic studies have advanced our understanding of heart failure with preserved ejection fraction (HFpEF). Despite improved pathophysiologic insight, clinical trials have failed to identify an effective treatment for HFpEF. Invasive hemodynamic assessment can diagnose or exclude HFpEF, making it invaluable in understanding the basis of the disease. This article reviews the hemodynamic mechanisms underlying HFpEF and how they manifest clinically, discusses invasive hemodynamic assessment as a diagnostic tool, and explores how invasive hemodynamic profiling may allow understanding of pathophysiological differences and inform the design and entry criteria for future trials.

Keywords: Dyspnea; Heart failure with preserved ejection fraction; Invasive hemodynamic assessment.

Publication types

  • Review

MeSH terms

  • Aged
  • Aged, 80 and over
  • Blood Flow Velocity
  • Diastole / physiology
  • Exercise Test / methods*
  • Female
  • Heart Failure / diagnosis*
  • Heart Function Tests
  • Hemodynamics / physiology*
  • Humans
  • Male
  • Middle Aged
  • Reference Values
  • Sensitivity and Specificity
  • Severity of Illness Index
  • Stroke Volume / physiology*
  • Syndrome
  • Systole / physiology
  • Ventricular Function, Left / physiology