Reduction of blood lipid parameters by a 12-wk supplementation of aged black garlic: a randomized controlled trial

Nutrition. 2014 Sep;30(9):1034-9. doi: 10.1016/j.nut.2014.02.014. Epub 2014 Mar 12.


Objective: The cholesterol-lowering effects of garlic as part of a healthy diet remain controversial. The aim of this study was to investigate whether supplementation with aged black garlic (ABG) could improve blood lipid profiles in patients with mild hypercholesterolemia.

Methods: We conducted a double-blind, randomized placebo-controlled trial. Sixty participants were randomly assigned to receive either ABG or placebo twice daily (total 6 g/d) before consumption of a meal every morning and evening for 12 wk. During the study, two participants dropped out of the ABG group, and three participants dropped out of the placebo group. Thus, the effects of AGB on fasting blood levels of lipids were evaluated in 28 participants and compared with the placebo group (n = 27).

Results: Among lipid components, no significant differences in triglycerides, low-density lipoprotein cholesterol, total cholesterol, or free fatty acid levels were observed between the two groups. However, ABG increased high-density lipoprotein cholesterol levels compared with the placebo group at the end of the study. Moreover, a significant decrease in the levels of alipoprotein B and a significant increase in the ratio of low-density lipoprotein cholesterol/alipoprotein B were observed in the ABG group. No adverse effects were reported in any of the patients.

Conclusion: ABG supplementation reduced atherogenic markers and thus may have a cardioprotective effect beyond the gold standard medication in patients with mild hypercholesterolemia.

Keywords: Aqueous extraction; Atherogenic marker; Cholesterol; Clinical trial; Garlic.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anticholesteremic Agents / pharmacology
  • Anticholesteremic Agents / therapeutic use
  • Apolipoproteins B / blood*
  • Cholesterol, HDL / blood*
  • Cholesterol, LDL / blood*
  • Dietary Supplements*
  • Double-Blind Method
  • Female
  • Garlic*
  • Humans
  • Hypercholesterolemia / blood
  • Hypercholesterolemia / drug therapy*
  • Lipids / blood
  • Male
  • Middle Aged
  • Plant Preparations / pharmacology
  • Plant Preparations / therapeutic use*
  • Triglycerides / blood


  • Anticholesteremic Agents
  • Apolipoproteins B
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Lipids
  • Plant Preparations
  • Triglycerides