Herbal extract SH003 suppresses tumor growth and metastasis of MDA-MB-231 breast cancer cells by inhibiting STAT3-IL-6 signaling

Mediators Inflamm. 2014;2014:492173. doi: 10.1155/2014/492173. Epub 2014 May 25.


Cancer inflammation promotes cancer progression, resulting in a high risk of cancer. Here, we demonstrate that our new herbal extract, SH003, suppresses both tumor growth and metastasis of MDA-MB-231 breast cancer cells via inhibiting STAT3-IL-6 signaling path. Our new herbal formula, SH003, mixed extract from Astragalus membranaceus, Angelica gigas, and Trichosanthes kirilowii Maximowicz, suppressed MDA-MB-231 tumor growth and lung metastasis in vivo and reduced the viability and metastatic abilities of MDA-MB-231 cells in vitro. Furthermore, SH003 inhibited STAT3 activation, which resulted in a reduction of IL-6 production. Therefore, we conclude that SH003 suppresses highly metastatic breast cancer growth and metastasis by inhibiting STAT3-IL-6 signaling path.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angelica / chemistry
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Astragalus propinquus / chemistry
  • Breast Neoplasms / metabolism*
  • Cell Line, Tumor
  • Cell Movement / drug effects
  • Cell Proliferation / drug effects
  • Female
  • Humans
  • Interleukin-6 / metabolism*
  • Plant Extracts / pharmacology*
  • STAT3 Transcription Factor / metabolism*
  • Signal Transduction / drug effects
  • Trichosanthes / chemistry


  • Antineoplastic Agents, Phytogenic
  • Interleukin-6
  • Plant Extracts
  • STAT3 Transcription Factor