Temperature thresholds in assessment of the clinical course of acquired cold contact urticaria: a prospective observational one-year study

Acta Derm Venereol. 2015 Mar;95(3):278-82. doi: 10.2340/00015555-1918.


Cold contact urticaria is the second most common subtype of physical urticaria. Cold stimulation standardized tests are mandatory to confirm the diagnosis. The aim of this study is to define the utility of determining thresholds (critical time and temperature) in assessment of the clinical course of typical acquired cold contact urticaria. Nineteen adult patients (10 women and 9 men; mean age 45 years) were included in the study and the diagnosis was confirmed with the ice-cube test and TempTest 3.0. Patients were treated continuously for 1 year with 20 mg/day rupatadine (anti-H1). Thresholds measurements were made before and after treatment. Improvements in temperature and critical time thresholds were found in the study sample, demonstrating the efficacy of continuous treatment with rupatadine. In most cases association with a clinical improvement was found. We propose an algorithm for the management of acquired cold contact urticaria based on these results.

Publication types

  • Observational Study

MeSH terms

  • Adult
  • Algorithms
  • Cold Temperature / adverse effects*
  • Critical Pathways
  • Cyproheptadine / analogs & derivatives*
  • Cyproheptadine / therapeutic use
  • Female
  • Histamine H1 Antagonists, Non-Sedating / therapeutic use*
  • Humans
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Prospective Studies
  • Sensory Thresholds*
  • Thermosensing*
  • Time Factors
  • Treatment Outcome
  • Urticaria / diagnosis*
  • Urticaria / drug therapy
  • Urticaria / etiology
  • Urticaria / psychology*


  • Histamine H1 Antagonists, Non-Sedating
  • rupatadine
  • Cyproheptadine