Peripheral biomarkers of oxidative stress and their limited potential in evaluation of clinical features of Huntington's patients

Biomarkers. 2014 Sep;19(6):452-6. doi: 10.3109/1354750X.2014.935955. Epub 2014 Jul 1.

Abstract

Context: Peripheral oxidative biomarkers could be useful for monitoring clinical features of Huntington's disease (HD).

Materials and methods: Cu/Zn-superoxide dismutase (Cu/Zn-SOD), neuron-specific enolase (NSE) and 8-hydroxy-2'-deoxyguanosine (8-oxoGua) serum levels were analysed in 18 HD patients and 10 controls. Clinical measures were recorded from each HD patients.

Results: Cu/Zn-SOD, NSE and 8-oxoGua values were higher in HD patients than in controls. Cu/Zn-SOD and NSE correlated positively. No correlation was observed between the biomarkers analysed and the clinical measures assessed.

Discussion and conclusion: Serum oxidative biomarkers could express the neuronal oxidative processes going on in HD patients but are inadequate to evaluate clinical features of the disease.

Keywords: Biomarkers; Huntington's disease; neuronal oxidative damage; oxidative stress.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 8-Hydroxy-2'-Deoxyguanosine
  • Adult
  • Biomarkers / blood
  • Case-Control Studies
  • Deoxyguanosine / analogs & derivatives
  • Deoxyguanosine / blood
  • Female
  • Humans
  • Huntington Disease / blood*
  • Male
  • Middle Aged
  • Oxidative Stress*
  • Phosphopyruvate Hydratase / blood
  • Superoxide Dismutase / blood

Substances

  • Biomarkers
  • 8-Hydroxy-2'-Deoxyguanosine
  • Superoxide Dismutase
  • Phosphopyruvate Hydratase
  • Deoxyguanosine