Acute respiratory failure secondary to eosinophilic pneumonia following influenza vaccination in an elderly man with chronic obstructive pulmonary disease

Int J Infect Dis. 2014 Sep;26:14-6. doi: 10.1016/j.ijid.2014.04.019. Epub 2014 Jun 27.


Acute respiratory failure with diffuse pulmonary opacities is an unusual manifestation following influenza vaccination. We report herein a patient with chronic obstructive pulmonary disease who developed fever with worsening of respiratory symptoms and severe hypoxemia requiring ventilatory support shortly after influenza vaccination. Bronchoalveolar lavage was compatible with acute eosinophilic pneumonia. Rapid clinical improvement was observed 2 weeks after systemic corticosteroid treatment, followed by radiographic improvement at 4 weeks. No disease recurrence was observed at the 6-month follow-up.

Keywords: Acute respiratory failure; Diffuse lung disease; Eosinophilic pneumonia; Influenza vaccination.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Humans
  • Influenza Vaccines / adverse effects*
  • Lung / diagnostic imaging
  • Male
  • Pulmonary Disease, Chronic Obstructive / complications*
  • Pulmonary Eosinophilia / diagnosis
  • Pulmonary Eosinophilia / drug therapy
  • Pulmonary Eosinophilia / etiology*
  • Radiography
  • Respiratory Distress Syndrome / diagnosis
  • Respiratory Distress Syndrome / etiology*
  • Vaccination


  • Influenza Vaccines