Comparative genetics of longevity and cancer: insights from long-lived rodents

Nat Rev Genet. 2014 Aug;15(8):531-40. doi: 10.1038/nrg3728. Epub 2014 Jul 1.


Mammals have evolved a remarkable diversity of ageing rates. Within the single order of Rodentia, maximum lifespans range from 4 years in mice to 32 years in naked mole rats. Cancer rates also differ substantially between cancer-prone mice and almost cancer-proof naked mole rats and blind mole rats. Recent progress in rodent comparative biology, together with the emergence of whole-genome sequence information, has opened opportunities for the discovery of genetic factors that control longevity and cancer susceptibility.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aging / genetics
  • Animals
  • Genetic Association Studies
  • Longevity / genetics*
  • Mice
  • Neoplasms / genetics*
  • Rats
  • Rodentia
  • Species Specificity