Vesicles as a tool for transdermal and dermal delivery

P Loan Honeywell-Nguyen; Joke A Bouwstra

doi:10.1016/j.ddtec.2005.05.003

Vesicles as a tool for transdermal and dermal delivery

Drug Discov Today Technol. 2005 Spring;2(1):67-74. doi: 10.1016/j.ddtec.2005.05.003.

Authors

P Loan Honeywell-Nguyen¹, Joke A Bouwstra²

Affiliations

¹ N. V. Organon, P.O. Box 20, 5340 BH Oss, The Netherlands.
² Division of Drug Delivery Technology, Leiden/Amsterdam Center for Drug Research, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands. Electronic address:bouwstra@chem.leidenuniv.nl.

PMID: 24981757
DOI: 10.1016/j.ddtec.2005.05.003

Abstract

Transdermal and dermal drug delivery is problematic because the skin, as a natural barrier, has a very low permeation rate. Therefore several methods have been assessed to increase this rate locally and temporarily. One approach is the use of vesicle formulations. In this paper the effectiveness of conventional and deformable vesicles as drug delivery systems as well as their possible mode of action as permeation enhancers or transdermal drug carriers will be discussed.: