Coumamidines, new broad spectrum antibiotics of the cinodine type. II. Isolation and structural elucidation

J Antibiot (Tokyo). 1989 Apr;42(4):533-7. doi: 10.7164/antibiotics.42.533.

Abstract

Two novel, isomeric compounds, coumamidines gamma 1 and gamma 2, were isolated from fermentations of an actinomycete. The structures were elucidated spectroscopically using 2D NMR correlation experiments and mass spectral data. The coumamidines were found to be close structural relatives of the cinodines (LL-BM123 gamma 1 and gamma 2).

MeSH terms

  • Actinomycetales / metabolism*
  • Aminoglycosides*
  • Anti-Bacterial Agents / analysis*
  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology
  • Chromatography, Gel
  • Fermentation
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Molecular Structure
  • Pseudomonas aeruginosa / drug effects

Substances

  • Aminoglycosides
  • Anti-Bacterial Agents
  • coumamidine gamma2
  • coumamidine gamma1