Abstract
An I(2)O(5)-promoted free-radical cascade trifluoromethylation/cyclization of a broad range of N-arylmethacrylamides and enynes with sodium trifluoromethanesulfinate in aqueous medium has been achieved. This strategy allows highly selective access to a variety of CF(3)-containing oxindoles and pyrrolidines. Electron spin resonance (ESR) studies indicate that atom-transfer processes are involved in this system.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acrylamides / chemistry*
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Alkynes / chemistry*
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Catalysis
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Cyclization
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Electron Spin Resonance Spectroscopy
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Free Radicals
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Hydrocarbons, Fluorinated / chemical synthesis*
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Hydrocarbons, Fluorinated / chemistry
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Indoles / chemical synthesis*
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Indoles / chemistry
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Iodine Compounds / chemistry*
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Molecular Structure
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Oxides / chemistry*
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Oxindoles
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Sodium / chemistry
Substances
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Acrylamides
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Alkynes
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Free Radicals
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Hydrocarbons, Fluorinated
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Indoles
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Iodine Compounds
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Oxides
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Oxindoles
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2-oxindole
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Sodium
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methacrylamide
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iodine pentoxide