Using evidence to combat overdiagnosis and overtreatment: evaluating treatments, tests, and disease definitions in the time of too much

PLoS Med. 2014 Jul 1;11(7):e1001655. doi: 10.1371/journal.pmed.1001655. eCollection 2014 Jul.


Ray Moynihan and colleagues outline suggestions for improving the way that medical evidence is produced, analysed, and interpreted to avoid problems of overdiagnosis and overtreatment.

Please see later in the article for the Editors' Summary

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Clinical Trials as Topic
  • Diagnosis*
  • Evidence-Based Medicine / methods*
  • Evidence-Based Medicine / standards*
  • Risk Assessment
  • Terminology as Topic
  • Therapeutics*

Grant support

There was no funding for this article, though Karel G.M. Moons gratefully acknowledges financial contribution by the Netherlands Organisation for Scientific Research (project 9120.8004 and 918.10.615). No funding bodies had any role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.