Oxidative balance score and oxidative stress biomarkers in a study of Whites, African Americans, and African immigrants

Biomarkers. 2014 Sep;19(6):471-80. doi: 10.3109/1354750X.2014.937361. Epub 2014 Jul 2.

Abstract

Context: Oxidative balance score (OBS) is a composite measure of multiple pro- and antioxidant exposures.

Objective: To investigate associations of OBS with F2-isoprostanes (FIP), mitochondrial DNA copy number (mtDNA), and fluorescent oxidative products (FOP), and assess inter-relationships among the biomarkers.

Methods: In a cross-sectional study, associations of a thirteen-component OBS with biomarker levels were assessed using multivariable regression models.

Results: Association of OBS with FIP, but not with FOP, was in the hypothesized direction. The results for mtDNA were unstable and analysis-dependent. The three biomarkers were not inter-correlated.

Conclusions: Different biomarkers of oxidative stress may reflect different biological processes.

Keywords: Oxidative balance; oxidative stress; race.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Africa, Western / ethnology
  • African Americans
  • Biomarkers / blood
  • Carotenoids / blood
  • Cross-Sectional Studies
  • Cryptoxanthins / blood
  • DNA, Mitochondrial / genetics
  • Diet
  • European Continental Ancestry Group
  • Gene Dosage
  • Humans
  • Isoprostanes / blood
  • Lycopene
  • Middle Aged
  • Oxidative Stress*
  • Sensitivity and Specificity
  • Zeaxanthins / blood
  • beta Carotene / blood

Substances

  • Biomarkers
  • Cryptoxanthins
  • DNA, Mitochondrial
  • Isoprostanes
  • Zeaxanthins
  • beta Carotene
  • Carotenoids
  • alpha-carotene
  • Lycopene