Bone morbidity in childhood leukemia: epidemiology, mechanisms, diagnosis, and treatment

doi:10.1007/s11914-014-0222-3

Review

. 2014 Sep;12(3):300-12.

doi: 10.1007/s11914-014-0222-3.

Bone morbidity in childhood leukemia: epidemiology, mechanisms, diagnosis, and treatment

Sogol Mostoufi-Moab¹, Jacqueline Halton

Affiliations

Affiliation

¹ Department of Pediatrics, The Children's Hospital of Philadelphia, The University of Pennsylvania Perelman School of Medicine, 34th Street and Civic Center Boulevard, Philadelphia, PA, 19104, USA, moab@email.chop.edu.

PMID: 24986711
PMCID: PMC4131149
DOI: 10.1007/s11914-014-0222-3

Free PMC article

Review

Bone morbidity in childhood leukemia: epidemiology, mechanisms, diagnosis, and treatment

Sogol Mostoufi-Moab et al. Curr Osteoporos Rep. 2014 Sep.

Free PMC article

. 2014 Sep;12(3):300-12.

doi: 10.1007/s11914-014-0222-3.

Authors

Sogol Mostoufi-Moab¹, Jacqueline Halton

Affiliation

¹ Department of Pediatrics, The Children's Hospital of Philadelphia, The University of Pennsylvania Perelman School of Medicine, 34th Street and Civic Center Boulevard, Philadelphia, PA, 19104, USA, moab@email.chop.edu.

PMID: 24986711
PMCID: PMC4131149
DOI: 10.1007/s11914-014-0222-3

Abstract

Skeletal abnormalities are commonly seen in children and adolescents with leukemia. The spectrum ranges from mild pain to debilitating osteonecrosis (ON) and fractures. In this review, we summarize the skeletal manifestations, provide an update on therapeutic strategies for prevention and treatment, and discuss the most recent advances in musculoskeletal research. Early recognition of skeletal abnormalities and strategies to optimize bone health are essential to prevent long-term skeletal sequelae and diminished quality of life observed in children and adolescents with leukemia.

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Conflict of interest statement

S. Mostoufi-Moab and J. Halton declare that they have no conflicts of interest.

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References

1. Leonard MB, Elmi A, Mostoufi-Moab S, et al. Effects of sex, race, and puberty on cortical bone and the functional muscle bone unit in children, adolescents, and young adults. J Clin Endocrinol Metab. 2010;95(4):1681–1689. - PMC - PubMed
1. Leonard MB. Glucocorticoid-induced osteoporosis in children: impact of the underlying disease. Pediatrics. 2007;119(Suppl 2):S166–S174. - PubMed
1. Sun L, Blair HC, Peng Y, et al. Calcineurin regulates bone formation by the osteoblast. Proc Natl Acad Sci U S A. 2005;102(47):17130–17135. - PMC - PubMed
1. Baty JM, Vogt EC. Bone changes of leukemia in children. Am J Roentgenol. 1935;34:310–313.
1. Simmons CR, Harle TS, Singleton EB. The osseous manifestations of leukemia in children. Radiol Clin N Am. 1968;6(1):115–130. - PubMed

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[1] Leonard MB, Elmi A, Mostoufi-Moab S, et al. Effects of sex, race, and puberty on cortical bone and the functional muscle bone unit in children, adolescents, and young adults. J Clin Endocrinol Metab. 2010;95(4):1681–1689. - PMC - PubMed

[2] Leonard MB, Elmi A, Mostoufi-Moab S, et al. Effects of sex, race, and puberty on cortical bone and the functional muscle bone unit in children, adolescents, and young adults. J Clin Endocrinol Metab. 2010;95(4):1681–1689. - PMC - PubMed

[3] Leonard MB. Glucocorticoid-induced osteoporosis in children: impact of the underlying disease. Pediatrics. 2007;119(Suppl 2):S166–S174. - PubMed

[4] Leonard MB. Glucocorticoid-induced osteoporosis in children: impact of the underlying disease. Pediatrics. 2007;119(Suppl 2):S166–S174. - PubMed

[5] Sun L, Blair HC, Peng Y, et al. Calcineurin regulates bone formation by the osteoblast. Proc Natl Acad Sci U S A. 2005;102(47):17130–17135. - PMC - PubMed

[6] Sun L, Blair HC, Peng Y, et al. Calcineurin regulates bone formation by the osteoblast. Proc Natl Acad Sci U S A. 2005;102(47):17130–17135. - PMC - PubMed

[7] Baty JM, Vogt EC. Bone changes of leukemia in children. Am J Roentgenol. 1935;34:310–313.

[8] Baty JM, Vogt EC. Bone changes of leukemia in children. Am J Roentgenol. 1935;34:310–313.

[9] Simmons CR, Harle TS, Singleton EB. The osseous manifestations of leukemia in children. Radiol Clin N Am. 1968;6(1):115–130. - PubMed

[10] Simmons CR, Harle TS, Singleton EB. The osseous manifestations of leukemia in children. Radiol Clin N Am. 1968;6(1):115–130. - PubMed

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Bone morbidity in childhood leukemia: epidemiology, mechanisms, diagnosis, and treatment

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Bone morbidity in childhood leukemia: epidemiology, mechanisms, diagnosis, and treatment

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