Imaging, genetic testing, and biomarker assessment of follicular cell-derived thyroid cancer

Ann Med. 2014 Sep;46(6):409-16. doi: 10.3109/07853890.2014.923739. Epub 2014 Jul 2.


Thyroid carcinoma is the most common endocrine malignancy worldwide, and its incidence continues to increase. As such the approach to a recently identified thyroid nodule is important to understand. The relevant imaging, examination, and need for fine-needle aspiration biopsy (FNA) are discussed. In approximately 25% of nodules, the diagnosis cannot be established with FNA-based cytology, and surgical excision is necessary for definitive diagnosis. Recent advances in genetic and molecular testing may increase the diagnostic accuracy of FNA in managing thyroid nodules.

Keywords: BRAF; Key words:; MiRInform; RET/PTC; Ras; gene expression classifier.

Publication types

  • Review

MeSH terms

  • Adenocarcinoma, Follicular / diagnosis*
  • Adenocarcinoma, Follicular / diagnostic imaging
  • Adenocarcinoma, Follicular / genetics
  • Genetic Markers / genetics
  • Genetic Testing
  • Humans
  • Radiography
  • Thyroid Gland / diagnostic imaging
  • Thyroid Neoplasms / diagnosis*
  • Thyroid Neoplasms / diagnostic imaging
  • Thyroid Neoplasms / genetics
  • Ultrasonography


  • Genetic Markers

Supplementary concepts

  • Thyroid cancer, follicular