Improvement in symptoms and cochlear flow with pycnogenol in patients with Meniere's disease and tinnitus

Minerva Med. 2014 Jun;105(3):245-54.

Abstract

Aim: The aim of this supplement registry was to evaluate the efficacy of the Pycnogenol® in improving cochlear flow and symptoms in a 6-month follow-up for patients with Meniere's disease (MD), tinnitus and cochlear hypoperfusion.

Methods: Main signs/symptoms were considered: Spontaneous vertigo, positional vertigo, hearing loss, tinnitus, pressure in the ear, unsteady gait, associated clinical problems, alterations in daily life. All subjects were managed with the best available management (BM); one group used the supplement Pycnogenol (150 mg/day). Cochlear flow and tinnitus were also evaluated. Out of 120 patients incuded in the registry, 55 used Pycnogenol and 52 (controls) were managed only with BM.

Results: There was a more significant improvement in all registry items at 3 and 6 months in the Pycnogenol group (P<0.05). The number of lost working days was lower in the Pycnogenol group. At 3 months, 45.4% of subjects using Pycnogenol were completely asymptomatic in comparison with 23.07% of controls. At 6 months 87.3% of the Pycnogenol subjects were asymptomatic compared with 34.6% of controls. Cochlear flow velocity was significantly better (higher flow, higher diastolic component) in the Pycnogenol group (P<0.05). The subjective tinnitus scale decreased in both groups (P<0.05); the decrease was more significant in Pycnogenol subjects (P<0.05) at 3 and 6 months.

Conclusion: Symptoms of Meniere's disease, flow at cochlear level and tinnitus improved in Pycnogenol subjects in comparison with best management.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Blood Flow Velocity / drug effects
  • Cochlea / blood supply*
  • Female
  • Flavonoids / therapeutic use*
  • Humans
  • Male
  • Meniere Disease / complications
  • Meniere Disease / diagnosis
  • Meniere Disease / drug therapy*
  • Middle Aged
  • Plant Extracts
  • Platelet Aggregation Inhibitors / therapeutic use*
  • Regional Blood Flow / drug effects
  • Registries
  • Time Factors
  • Tinnitus / drug therapy*
  • Tinnitus / etiology
  • Treatment Outcome

Substances

  • Flavonoids
  • Plant Extracts
  • Platelet Aggregation Inhibitors
  • pycnogenols