SnapShot: sirtuins, NAD, and aging

Cell Metab. 2014 Jul 1;20(1):192-192.e1. doi: 10.1016/j.cmet.2014.06.001.


Sirtuins are highly conserved nicotinamide adenine dinucleotide (NAD)-dependent enzymes that regulate a wide range of biological processes, including aging, in several species. This SnapShot provides a comprehensive overview of the targets, enzymatic activities, and physiological functions of the seven mammalian sirtuins, as well as the regulation of the biosynthetic pathways regulating NAD availability.

MeSH terms

  • Aging*
  • Caloric Restriction
  • Histones / metabolism
  • Humans
  • NAD / metabolism*
  • Sirtuins / metabolism*


  • Histones
  • NAD
  • Sirtuins