Physiological functions and underlying mechanisms of fibroblast growth factor (FGF) family members: recent findings and implications for their pharmacological application

Biol Pharm Bull. 2014;37(7):1081-9. doi: 10.1248/bpb.b14-00265.

Abstract

Despite their name, fibroblast growth factors (FGFs) are multifunctional regulators affecting a wide variety of physiological events. This review summarizes our recent studies on FGFs from mechanistic, physiological and application-oriented viewpoints. These include studies on the importance of βKlotho and glycosaminoglycans for the signaling of hormonal FGFs (FGF21 and FGF19); the physiological role of a paracrine FGF (FGF18) in hair cycle regulation; and the development of a stable, chimeric FGF protein composed of FGF1 and FGF2 domains suitable for radioprotection.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Line
  • Fibroblast Growth Factors / genetics
  • Fibroblast Growth Factors / pharmacology*
  • Fibroblast Growth Factors / physiology*
  • Hair Follicle / growth & development
  • Hair Follicle / metabolism
  • Humans
  • Klotho Proteins
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism
  • Radiation Injuries, Experimental / prevention & control
  • Radiation-Protective Agents / pharmacology
  • Receptors, Fibroblast Growth Factor / genetics
  • Receptors, Fibroblast Growth Factor / metabolism
  • Recombinant Fusion Proteins / pharmacology
  • Signal Transduction*

Substances

  • KLB protein, human
  • Membrane Proteins
  • Radiation-Protective Agents
  • Receptors, Fibroblast Growth Factor
  • Recombinant Fusion Proteins
  • Fibroblast Growth Factors
  • Klotho Proteins