Lithium increases slow wave sleep: possible mediation by brain 5-HT2 receptors?

K J Friston; A L Sharpley; R A Solomon; P J Cowen

doi:10.1007/BF00442020

Lithium increases slow wave sleep: possible mediation by brain 5-HT2 receptors?

Psychopharmacology (Berl). 1989;98(1):139-40. doi: 10.1007/BF00442020.

Authors

K J Friston¹, A L Sharpley, R A Solomon, P J Cowen

Affiliation

¹ MRC Unit of Clinical Pharmacology, Littlemore Hospital, Oxford, UK.

PMID: 2498958
DOI: 10.1007/BF00442020

Abstract

The effect of lithium on slow wave sleep (SWS) was studied in ten normal male volunteers using home based cassette sleep recording and automatic sleep stage analysis. Lithium increased SWS, an effect consistent with a reduction in brain 5-HT2 receptor function.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Electroencephalography
Humans
Lithium / pharmacology*
Male
Receptors, Serotonin / drug effects
Receptors, Serotonin / physiology*
Sleep / drug effects*
Sleep Stages / drug effects

Substances

Receptors, Serotonin
Lithium