Cohort Profile: The Ecuador Life (ECUAVIDA) study in Esmeraldas Province, Ecuador

Int J Epidemiol. 2015 Oct;44(5):1517-27. doi: 10.1093/ije/dyu128. Epub 2014 Jul 2.


The ECUAVIDA birth cohort is studying the impact of exposures to soil-transmitted helminth (STH) parasites and early-life microbial exposures on the development of atopy, allergic diseases and immune responses in childhood. A total of 2404 newborns were recruited between 2006 and 2009 in a public hospital serving the rural district of Quininde, Esmeraldas Province, in a tropical region of coastal Ecuador. Detailed measurements were done around the time of the birth, at 7 and 13 months and at 2 and 3 years, and data collection is ongoing at 5 and 8 years. Data being collected include questionnaires for: sociodemographic, lifestyle, psychosocial (at 4-6 years only) and dietary (at 6-7 years only) factors; childhood morbidity and clinical outcomes; stool samples for parasites; blood samples for DNA, measurements of vaccine responses and other measures of immune function/inflammation; and anthropometrics. Allergen skin prick test reactivity is done from 2 years and measures of airway function and inflammation at 8 years.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Asthma / epidemiology
  • Child
  • Child, Preschool
  • Ecuador
  • Eczema / epidemiology
  • Environmental Exposure*
  • Female
  • Helminthiasis / epidemiology*
  • Humans
  • Hypersensitivity, Immediate / epidemiology*
  • Immunity, Innate
  • Infant
  • Infant, Newborn
  • Male
  • Pregnancy
  • Pregnancy Complications, Parasitic / epidemiology*
  • Prospective Studies
  • Rural Population
  • Skin Tests
  • Surveys and Questionnaires
  • Young Adult