Disc haemorrhage is associated with the fast component, but not the slow component, of visual field decay rate in glaucoma

Joon Mo Kim; Haksu Kyung; Parham Azarbod; Jun Mo Lee; Joseph Caprioli

doi:10.1136/bjophthalmol-2013-304584

Disc haemorrhage is associated with the fast component, but not the slow component, of visual field decay rate in glaucoma

Br J Ophthalmol. 2014 Nov;98(11):1555-9. doi: 10.1136/bjophthalmol-2013-304584. Epub 2014 Jul 2.

Authors

Joon Mo Kim¹, Haksu Kyung², Parham Azarbod³, Jun Mo Lee⁴, Joseph Caprioli⁵

Affiliations

¹ Department of Ophthalmology, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital, Seoul, Korea Department of Ophthalmology, Jules Stein Eye Institute, University of California Los Angeles School of Medicine, Los Angeles, California, USA.
² Department of Ophthalmology, Jules Stein Eye Institute, University of California Los Angeles School of Medicine, Los Angeles, California, USA Department of Ophthalmology, National Medical Center, Seoul, Korea.
³ Department of Ophthalmology, Jules Stein Eye Institute, University of California Los Angeles School of Medicine, Los Angeles, California, USA Moorfields Eye Hospital, London, UK.
⁴ Department of Ophthalmology, Jules Stein Eye Institute, University of California Los Angeles School of Medicine, Los Angeles, California, USA Siloam eye hospital, Seoul, Korea.
⁵ Department of Ophthalmology, Jules Stein Eye Institute, University of California Los Angeles School of Medicine, Los Angeles, California, USA.

PMID: 24990873
DOI: 10.1136/bjophthalmol-2013-304584

Abstract

Background/aims: To investigate the association of disc haemorrhage (DH) with regional visual field (VF) decay in glaucoma.

Methods: Retrospective longitudinal study was performed. Patients from the University of California, Los Angeles, glaucoma database were assigned to two groups based on the presence or absence of a DH. Pointwise exponential regression was used to identify the fast and slow rate components of VF decay. Associations between patient demographics, ocular and systemic factors, and visual field rates were analysed.

Results: A total of 185 patients were included, 54 of whom were documented to have a DH at some point during their course. DH group had a higher female preponderance (p=0.017, OR 2.23), a higher incidence of peripapillary atrophy (p=0.002, OR 4.46), more advanced disease (p=0.016) and a higher fast rate component of VF decay (p<0.001) than non-DH group. With multivariate logistic regression analysis, only the fast rate component showed a statistically significant relationship with DH.

Conclusions: The presence of DH is associated with a greater fast component rate of VF decay. The identification and monitoring of the fast component of VF decay may prove useful in the identification and management of glaucoma patients at high risk of progression.

Keywords: Glaucoma.

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Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Disease Progression
False Positive Reactions
Female
Glaucoma, Open-Angle / physiopathology*
Humans
Longitudinal Studies
Male
Middle Aged
Optic Disk / physiopathology*
Predictive Value of Tests
Reproducibility of Results
Retinal Hemorrhage / physiopathology*
Retrospective Studies
Vision Disorders / physiopathology*
Visual Field Tests
Visual Fields / physiology*