Neuregulin-ERBB signaling in the nervous system and neuropsychiatric diseases

Neuron. 2014 Jul 2;83(1):27-49. doi: 10.1016/j.neuron.2014.06.007.


Neuregulins (NRGs) comprise a large family of growth factors that stimulate ERBB receptor tyrosine kinases. NRGs and their receptors, ERBBs, have been identified as susceptibility genes for diseases such as schizophrenia (SZ) and bipolar disorder. Recent studies have revealed complex Nrg/Erbb signaling networks that regulate the assembly of neural circuitry, myelination, neurotransmission, and synaptic plasticity. Evidence indicates there is an optimal level of NRG/ERBB signaling in the brain and deviation from it impairs brain functions. NRGs/ERBBs and downstream signaling pathways may provide therapeutic targets for specific neuropsychiatric symptoms.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Central Nervous System / metabolism*
  • Central Nervous System / pathology
  • ErbB Receptors / genetics
  • ErbB Receptors / physiology*
  • Humans
  • Mental Disorders / genetics
  • Mental Disorders / metabolism*
  • Mental Disorders / psychology
  • Nerve Net / metabolism
  • Nerve Net / pathology
  • Signal Transduction / genetics
  • Signal Transduction / physiology*


  • EGFR protein, human
  • ErbB Receptors