Dynamic CT perfusion imaging of the myocardium using a wide-detector scanner: a semiquantitative analysis in an animal model

Clin Imaging. Sep-Oct 2014;38(5):675-80. doi: 10.1016/j.clinimag.2014.05.011. Epub 2014 Jun 2.


Background: Functional assessment of myocardial perfusion in computed tomography (CT) is a challenge.

Objective: To evaluate CT dynamic myocardial perfusion imaging (MPI) using a wide-detector scanner.

Methods: Time to peak (TTP), peak enhancement (PE), upslope (US), and the area under the curve (AUC) were calculated in 12 pigs (256-slice multidetector CT scanner).

Results: The entire myocardium was covered by the scan volume. TTP was increased, and PE, US, and AUC were decreased in poststenotic myocardium.

Conclusion: CT MPI with complete coverage of the myocardium is feasible, providing evaluation of the physiological significance of coronary artery stenosis.

Keywords: 256-Slice MDCT; Computed tomography; Coronary artery disease (CAD); Dynamic Myocardial perfusion; Ischemia.

MeSH terms

  • Animals
  • Coronary Circulation / physiology*
  • Equipment Design
  • Female
  • Multidetector Computed Tomography / instrumentation*
  • Myocardial Ischemia / diagnostic imaging*
  • Myocardial Ischemia / physiopathology
  • Myocardial Perfusion Imaging / methods*
  • Reproducibility of Results
  • Swine