Biomaterials for tissue engineering applications

Semin Pediatr Surg. 2014 Jun;23(3):112-8. doi: 10.1053/j.sempedsurg.2014.06.010. Epub 2014 Jun 5.


With advancements in biological and engineering sciences, the definition of an ideal biomaterial has evolved over the past 50 years from a substance that is inert to one that has select bioinductive properties and integrates well with adjacent host tissue. Biomaterials are a fundamental component of tissue engineering, which aims to replace diseased, damaged, or missing tissue with reconstructed functional tissue. Most biomaterials are less than satisfactory for pediatric patients because the scaffold must adapt to the growth and development of the surrounding tissues and organs over time. The pediatric community, therefore, provides a distinct challenge for the tissue engineering community.

Keywords: Bioactive molecules; Biomaterials; Tissue engineering.

Publication types

  • Review

MeSH terms

  • Biocompatible Materials*
  • Child
  • Humans
  • Pediatrics / methods
  • Skin, Artificial
  • Tissue Engineering / methods*
  • Tissue Scaffolds


  • Biocompatible Materials