PML, SUMO, and RNF4: Guardians of Nuclear Protein Quality

Mol Cell. 2014 Jul 3;55(1):1-3. doi: 10.1016/j.molcel.2014.06.022.


In this issue of Molecular Cell, Guo et al. (2014) report that misfolded or aggregated nuclear proteins, such as pathogenic polyQ proteins, are cleared by a SUMO-dependent quality control pathway, which involves the E3 SUMO ligase PML and the SUMO-targeted ubiquitin ligase RNF4.

Publication types

  • Comment

MeSH terms

  • Animals
  • Humans
  • Nerve Degeneration / pathology*
  • Protein Folding*
  • Proteolysis*