Whole-genome sequencing analysis reveals high specificity of CRISPR/Cas9 and TALEN-based genome editing in human iPSCs

Cell Stem Cell. 2014 Jul 3;15(1):12-3. doi: 10.1016/j.stem.2014.06.011.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • CRISPR-Cas Systems / genetics*
  • Cell Line
  • Clustered Regularly Interspaced Short Palindromic Repeats / genetics
  • DNA Repair
  • Endonucleases / genetics
  • Endonucleases / metabolism*
  • Genetic Engineering
  • Genetic Therapy*
  • Genome / genetics
  • Humans
  • Induced Pluripotent Stem Cells / physiology*
  • Sequence Analysis, DNA / methods*
  • Zinc Fingers / genetics

Substances

  • Endonucleases