Aluminum in parenteral products: analysis, reduction, and implications for pediatric TPN

J Parenter Sci Technol. 1989 May-Jun;43(3):132-9.


Performance and cost of the best available analytical methodology for the measurement of aluminum in parenteral products are presented. Typical levels of aluminum in representative solutions are summarized. A methodical approach to the minimization of aluminum contamination in the manufacturing process is considered in light of aqueous aluminum chemical considerations. Results of long-term clinical follow-up studies of infants maintained on currently manufactured TPN solutions indicate no adverse pathology arising from aluminum.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Adult
  • Aluminum / adverse effects
  • Aluminum / analysis*
  • Bone Diseases / chemically induced
  • Chemical and Drug Induced Liver Injury
  • Drug Contamination* / analysis
  • Drug Contamination* / prevention & control
  • Humans
  • Infant
  • Parenteral Nutrition, Total / adverse effects*
  • Solutions / analysis
  • Solutions / standards


  • Solutions
  • Aluminum