Delivering nonidentical twins

Nat Struct Mol Biol. 2014 Aug;21(8):649-51. doi: 10.1038/nsmb.2852. Epub 2014 Jul 6.


Two sibling DNA polymerases synthesize most of the eukaryotic nuclear genome. A new study provides insights into the distinct protein interactions that deliver these replicases for asymmetric leading- and lagging-strand replication and reveals possible cross-talk between DNA replication and other cellular processes.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Comment

MeSH terms

  • DNA Polymerase II / chemistry*
  • DNA Polymerase III / chemistry*
  • DNA Replication*
  • Saccharomyces cerevisiae / enzymology*


  • DNA Polymerase II
  • DNA Polymerase III