Kilovoltage intrafraction motion monitoring and target dose reconstruction for stereotactic volumetric modulated arc therapy of tumors in the liver

Radiother Oncol. 2014 Jun;111(3):424-30. doi: 10.1016/j.radonc.2014.05.007. Epub 2014 Jul 2.


Purpose: To use intrafraction kilovoltage (kV) imaging during liver stereotactic body radiotherapy (SBRT) delivered by volumetric modulated arc therapy (VMAT) to estimate the intra-treatment target motion and to reconstruct the delivered target dose.

Methods: Six liver SBRT patients with 2-3 implanted gold markers received SBRT in three fractions of 18.75 Gy or 25 Gy. CTV-to-PTV margins of 5 mm in the axial plane and 10 mm in the cranio-caudal directions were applied. A VMAT plan was designed to give minimum target doses of 95% (CTV) and 67% (PTV). At each fraction, the 3D marker trajectory was estimated by fluoroscopic kV imaging throughout treatment delivery and used to reconstruct the actually delivered CTV dose. The reduction in D95 (minimum dose to 95% of the CTV) relative to the planned D95 was calculated.

Results: The kV position estimation had mean root-mean-square errors of 0.36 mm and 0.47 mm parallel and perpendicular to the kV imager, respectively. Intrafraction motion caused a mean 3D target position error of 2.9 mm and a mean D95 reduction of 6.0%. The D95 reduction correlated with the mean 3D target position error during a fraction.

Conclusions: Kilovoltage imaging for detailed motion monitoring with dose reconstruction of VMAT-based liver SBRT was demonstrated for the first time showing large dosimetric impact of intrafraction tumor motion.

Keywords: Dose reconstruction; Image-guided radiotherapy; Intrafraction motion monitoring.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Imaging, Three-Dimensional
  • Liver Neoplasms / pathology*
  • Liver Neoplasms / secondary
  • Liver Neoplasms / surgery*
  • Male
  • Middle Aged
  • Radiosurgery / methods*
  • Radiotherapy Planning, Computer-Assisted / methods*
  • Radiotherapy, Intensity-Modulated / methods