Multiple sclerosis patients lacking oligoclonal bands in the cerebrospinal fluid have less global and regional brain atrophy

J Neuroimmunol. 2014 Sep 15;274(1-2):149-54. doi: 10.1016/j.jneuroim.2014.06.010. Epub 2014 Jun 26.


To investigate whether multiple sclerosis (MS) patients with and without cerebrospinal fluid (CSF) oligoclonal immunoglobulin G bands (OCB) differ in brain atrophy. Twenty-eight OCB-negative and thirty-five OCB-positive patients were included. Larger volumes of total CSF and white matter (WM) lesions; smaller gray matter (GM) volume in the basal ganglia, diencephalon, cerebellum, and hippocampus; and smaller WM volume in corpus callosum, periventricular-deep WM, brainstem, and cerebellum, were observed in OCB-positives. OCB-negative patients, known to differ genetically from OCB-positives, are characterized by less global and regional brain atrophy. This finding supports the notion that OCB-negative MS patients may represent a clinically relevant MS subgroup.

Keywords: Brain atrophy; Cerebrospinal fluid; MRI; Multiple Esclerosis; Multivariate analyses; Oligoclonal bands.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Atrophy / cerebrospinal fluid
  • Atrophy / immunology
  • Atrophy / pathology
  • Brain / immunology
  • Brain / pathology
  • Brain Diseases / cerebrospinal fluid
  • Brain Diseases / immunology*
  • Brain Diseases / pathology
  • Disability Evaluation
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Multiple Sclerosis, Chronic Progressive / cerebrospinal fluid
  • Multiple Sclerosis, Chronic Progressive / immunology*
  • Multiple Sclerosis, Chronic Progressive / pathology
  • Multiple Sclerosis, Relapsing-Remitting / cerebrospinal fluid
  • Multiple Sclerosis, Relapsing-Remitting / immunology*
  • Multiple Sclerosis, Relapsing-Remitting / pathology
  • Multivariate Analysis
  • Oligoclonal Bands / cerebrospinal fluid
  • Oligoclonal Bands / immunology*


  • Oligoclonal Bands