Metagenomic small molecule discovery methods

Curr Opin Microbiol. 2014 Jun;19:70-75. doi: 10.1016/j.mib.2014.05.021. Epub 2014 Jul 5.


Metagenomic approaches to natural product discovery provide the means to harvest bioactive small molecules synthesized by environmental bacteria without the requirement of first culturing these organisms. Advances in sequencing technologies and general metagenomic methods are beginning to provide the tools necessary to unlock the unexplored biosynthetic potential encoded by the genomes of uncultured environmental bacteria. Here, we highlight recent advances in sequence-based and functional-based metagenomic approaches that promise to facilitate antibiotic discovery from diverse environmental microbiomes.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Bacteria / drug effects
  • Bacteria / genetics
  • Bacteria / metabolism
  • Metagenomics*
  • Small Molecule Libraries


  • Anti-Bacterial Agents
  • Small Molecule Libraries