The effect of applied chest compression force on systemic arterial pressure and end-tidal carbon dioxide concentration during CPR in human beings

Ann Emerg Med. 1989 Jul;18(7):732-7. doi: 10.1016/s0196-0644(89)80005-8.


Twelve adult (nine men and three women) cardiac arrest patients were studied as they received CPR by a computerized Thumper to determine the influence of the applied chest compression force on blood flow (as assessed by the end-tidal carbon dioxide concentration) and arterial pressure. At the end of a resuscitation when the decision was made by the senior physician to cease resuscitative efforts, the applied force on the CPR Thumper was decreased from 140 to 0 pound-force (lbf) in 20-lbf increments at 30-second intervals. Radial artery cutdown blood pressure and end-tidal carbon dioxide (ETCO2) were recorded continuously. Arterial systolic blood pressure was linearly related (r = .59, P less than .0001) to applied force (systolic blood pressure, 31 +/- 6 mm Hg at 20 lbf to 60 +/- 7 mm Hg at 140 lbf). ETCO2 (r = .42, P less than .0001) was also linearly related to applied force (ETCO2, 0.7 +/- 0.1% at 20 lbf to 1.5 +/- 0.2% at 140 lbf). Diastolic pressure did not change significantly with change in applied force (17 +/- 2 mm Hg from 20 to 140 lbf). Our findings indicate that higher compression force than that currently recommended may improve arterial systolic pressure and flow in human beings receiving closed-chest compression during CPR.

MeSH terms

  • Blood Pressure*
  • Breath Tests
  • Carbon Dioxide / analysis*
  • Female
  • Heart Arrest / therapy*
  • Humans
  • Male
  • Middle Aged
  • Pressure
  • Resuscitation / methods*


  • Carbon Dioxide