Endomyocardial fibrosis (EMF) in a Ugandan child with advanced hepatosplenic schistosomiasis: coincidence or connection?

Am J Trop Med Hyg. 2014 Oct;91(4):798-800. doi: 10.4269/ajtmh.14-0156. Epub 2014 Jul 7.

Abstract

An association between late-stage hepatosplenic schistosomiasis and endomyocardial fibrosis (EMF) has been suggested but not proven. We present the case of a 12-year-old Ugandan boy with striking comorbidities, including advanced periportal fibrosis caused by Schistosoma mansoni infection and right ventricular EMF, and discuss the possible correlation between both diseases.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthelmintics / therapeutic use
  • Child
  • Endomyocardial Fibrosis / complications*
  • Endomyocardial Fibrosis / drug therapy
  • Endomyocardial Fibrosis / parasitology
  • Feces / parasitology
  • Humans
  • Liver Diseases / complications*
  • Liver Diseases / drug therapy
  • Liver Diseases / parasitology
  • Male
  • Praziquantel / therapeutic use
  • Propranolol / therapeutic use
  • Schistosoma mansoni / isolation & purification*
  • Schistosomiasis mansoni / complications*
  • Schistosomiasis mansoni / drug therapy
  • Schistosomiasis mansoni / parasitology
  • Splenic Diseases / complications*
  • Splenic Diseases / drug therapy
  • Splenic Diseases / parasitology
  • Uganda
  • Vasodilator Agents / therapeutic use

Substances

  • Anthelmintics
  • Vasodilator Agents
  • Praziquantel
  • Propranolol