Adipokines as predictors of recovery from upper extremity soft tissue disorders

Rheumatology (Oxford). 2014 Dec;53(12):2238-42. doi: 10.1093/rheumatology/keu272. Epub 2014 Jul 7.

Abstract

Objectives: To study the associations of adipokines with recovery from upper extremity soft tissue disorders (UESTDs) and to explore whether overweight or obesity modify these associations.

Methods: In this follow-up study, patients seeking medical advice due to incipient upper extremity symptoms with symptom duration <1 month were included (n = 163). The outcome of the study was full or substantial recovery from UESTDs, assessed at 2, 8 and 12 weeks of follow-up. We studied the associations of four adipokines (leptin, adiponectin, resistin and visfatin) with recovery using the generalized estimating equation.

Results: Of the study population, 27.5% reported full or substantial recovery at the 8-week follow-up and 32% at 12 weeks. Higher levels of resistin [odds ratio (OR) = 1.58, 95% CI 1.18, 2.11 for 1 s.d. increase] and visfatin (OR = 1.29, 95% CI 0.94, 1.78 for 1 s.d. increase) at baseline predicted a higher recovery rate at the 8-week follow-up. Moreover, higher levels of leptin predicted a lower rate of recovery (OR = 0.73, 95% CI 0.51, 1.02 for 1 s.d. increase). Adipokines did not predict recovery at 12 weeks. In subgroup analyses, high levels of resistin and visfatin at baseline predicted a higher recovery rate during follow-up in non-overweight patients.

Conclusion: The adipokines resistin and visfatin predicted recovery from UESTDs and the associations may be related to stimulation of anti-inflammatory response mechanisms. A higher level of leptin may prevent recovery from UESTDs.

Keywords: adipokines; epicondylitis; obesity; rotator cuff tendinopathy; tenosynovitis; upper extremity disorders.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipokines / blood*
  • Adult
  • Biomarkers / blood
  • Cytokines / blood
  • Female
  • Follow-Up Studies
  • Humans
  • Leptin / blood
  • Male
  • Middle Aged
  • Musculoskeletal Diseases / blood
  • Musculoskeletal Diseases / complications
  • Musculoskeletal Diseases / diagnosis*
  • Nicotinamide Phosphoribosyltransferase / blood
  • Obesity / blood
  • Obesity / complications
  • Prognosis
  • Resistin / blood
  • Tendinopathy / blood
  • Tendinopathy / complications
  • Tendinopathy / diagnosis
  • Upper Extremity*

Substances

  • Adipokines
  • Biomarkers
  • Cytokines
  • Leptin
  • RETN protein, human
  • Resistin
  • Nicotinamide Phosphoribosyltransferase
  • nicotinamide phosphoribosyltransferase, human