Successful in Utero Intervention for Bilateral Renal Agenesis

Obstet Gynecol. 2014 Aug;124(2 Pt 2 Suppl 1):413-5. doi: 10.1097/AOG.0000000000000339.


Background: We report a case of bilateral renal agenesis treated with serial amnioinfusion in which the newborn survived the newborn period and was able to undergo peritoneal dialysis as a bridge to planned renal transplantation.

Case: A 34-year-old woman, gravida 1 para 0, presented at 23 1/7 weeks of gestation with a diagnosis of anhydramnios and bilateral renal agenesis. The patient underwent weekly serial amnioinfusion with the goal of improving fetal pulmonary development. At 28 weeks of gestation, the patient delivered a live newborn who required minimal respiratory support. The neonate is currently 9 months old and is undergoing daily peritoneal dialysis.

Conclusion: Serial amnioinfusion appears to have mitigated the severe pulmonary compromise that has, in the past, led to the death of newborns with bilateral renal agenesis.

Publication types

  • Case Reports

MeSH terms

  • Abnormalities, Multiple / etiology
  • Abnormalities, Multiple / prevention & control*
  • Adult
  • Congenital Abnormalities / therapy*
  • Female
  • Fetal Diseases / therapy*
  • Fetal Therapies*
  • Humans
  • Infant, Newborn
  • Kidney / abnormalities*
  • Kidney Diseases / complications
  • Kidney Diseases / congenital*
  • Kidney Diseases / therapy
  • Lung / abnormalities*
  • Lung Diseases / etiology
  • Lung Diseases / prevention & control*
  • Peritoneal Dialysis
  • Pregnancy

Supplementary concepts

  • Hereditary renal agenesis
  • Lung agenesis