Nuclear envelope breakdown: actin' quick to tear down the wall

Curr Biol. 2014 Jul 7;24(13):R605-7. doi: 10.1016/j.cub.2014.05.059.


Nuclear envelope breakdown in metazoan cells is thought to be facilitated by microtubules, which pull on the nuclear membranes. Unexpectedly, an F-actin meshwork helps to tear down the large nucleus of starfish oocytes and to prevent chromosome loss in meiosis.

MeSH terms

  • Actins / metabolism*
  • Animals
  • Meiosis / physiology*
  • Models, Biological*
  • Nuclear Envelope / metabolism*
  • Oocytes / cytology
  • Oocytes / physiology*
  • Starfish / physiology*


  • Actins