Balance exercise program reduced falls in people with multiple sclerosis: a single-group, pretest-posttest trial

Arch Phys Med Rehabil. 2014 Dec;95(12):2428-34. doi: 10.1016/j.apmr.2014.06.016. Epub 2014 Jul 6.


Objective: To evaluate the effects of a balance exercise program on falls in people with mild to moderate multiple sclerosis (MS).

Design: Multicenter, single-blinded, single-group, pretest-posttest trial.

Setting: Seven rehabilitation units within 5 county councils.

Participants: Community-dwelling adults with MS (N=32) able to walk 100m but unable to maintain 30-second tandem stance with arms alongside the body.

Intervention: Seven weeks of twice-weekly, physiotherapist-led 60-minute sessions of group-based balance exercise targeting core stability, dual tasking, and sensory strategies (CoDuSe).

Main outcome measures: Primary outcomes: number of prospectively reported falls and proportion of participants classified as fallers during 7 preintervention weeks, intervention period, and 7 postintervention weeks. Secondary outcomes: balance performance on the Berg Balance Scale, Four Square Step Test, sit-to-stand test, timed Up and Go test (alone and with cognitive component), and Functional Gait Assessment Scale; perceived limitations in walking on the 12-item MS Walking Scale; and balance confidence on the Activities-specific Balance Confidence Scale rated 7 weeks before intervention, directly after intervention, and 7 weeks later.

Results: Number of falls (166 to 43; P≤.001) and proportion of fallers (17/32 to 10/32; P≤.039) decreased significantly between the preintervention and postintervention periods. Balance performance improved significantly. No significant differences were detected for perceived limitations in walking, balance confidence, the timed Up and Go test, or sit-to-stand test.

Conclusions: The CoDuSe program reduced falls and proportion of fallers and improved balance performance in people with mild to moderate MS but did not significantly alter perceived limitations in walking and balance confidence.

Trial registration: NCT01582126.

Keywords: Accidental falls; Exercise; Multiple sclerosis; Postural balance; Rehabilitation; Walking.

Publication types

  • Clinical Trial
  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Accidental Falls / prevention & control*
  • Adult
  • Aged
  • Exercise Test
  • Exercise Therapy / methods*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Multiple Sclerosis / physiopathology*
  • Multiple Sclerosis / rehabilitation*
  • Postural Balance / physiology*
  • Single-Blind Method

Associated data