Clinical and radiographic evaluation of the efficacy of platelet-rich plasma combined with hydroxyapatite bone graft substitutes in the treatment of intra-bony defects in maxillofacial region

Acta Odontol Scand. 2014 Nov;72(8):948-53. doi: 10.3109/00016357.2014.926023. Epub 2014 Jul 9.


Objective: The aim of this study is to evaluate the efficacy of platelet-rich plasma (PRP) clinically and radiographically when combined with bovine derived hydroxyapatite (HA) bone grafting materials and resorbable collagen membranes for the treatment of intra-bony defects frequently seen at the distal aspect of mandibular second molars following the surgical extraction of fully impacted mandibular wisdom teeth.

Study design: Eighteen patients were scheduled for post-operative visits at 1, 3 and 6 months post-operatively, probing depths were measured and digital panoramic radiographs were taken.

Results: There were no significant differences on probing depths among two groups. Radiographic assessment also showed no significant difference among groups at 1st and 6th month intervals, while 3 months post-operatively the amount of radiographic density at the PRP side was significantly higher.

Conclusion: Combined use of PRP and bovine-derived HA graft materials for the treatment of intra-bony defects might be an appropriate approach when the main goal is providing earlier bone regeneration.

Keywords: bone healing; hydroxyapatite; platelet rich plasma.

Publication types

  • Comparative Study

MeSH terms

  • Absorbable Implants
  • Adolescent
  • Adult
  • Alveolar Bone Loss / surgery*
  • Animals
  • Bone Density / physiology
  • Bone Regeneration / physiology
  • Bone Substitutes / therapeutic use*
  • Cattle
  • Collagen
  • Durapatite / therapeutic use*
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Membranes, Artificial
  • Molar, Third / surgery
  • Periodontal Pocket / classification
  • Platelet-Rich Plasma / physiology*
  • Radiography, Dental, Digital
  • Radiography, Panoramic
  • Tooth Extraction / methods
  • Tooth Socket / surgery
  • Tooth, Impacted / surgery
  • Treatment Outcome
  • Young Adult


  • Bone Substitutes
  • Membranes, Artificial
  • Collagen
  • Durapatite