Genetics of aging, progeria and lamin disorders

Curr Opin Genet Dev. 2014 Jun;26:41-6. doi: 10.1016/j.gde.2014.05.003. Epub 2014 Jul 6.

Abstract

Premature aging disorders, like Werner syndrome, Bloom's syndrome, and Hutchinson-Gilford Progeria Syndrome (HGPS), have been the subjects of immense interest as they recapitulate many of the phenotypes observed in physiological aging. They, therefore, not only provide model systems to study normal aging processes but also give valuable insights into the intricate mechanisms underlying senescence. Recent works on HGPS have revealed alterations in a spectrum of cellular and molecular pathways involved in the maintenance of genomic integrity, thus suggesting a profound impact of the nuclear lamina in nuclear organization, chromatin dynamics, regulation of gene expression and epigenetics.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aging / genetics*
  • Chromatin Assembly and Disassembly
  • Epigenesis, Genetic / genetics
  • Genetic Predisposition to Disease / genetics*
  • Humans
  • Lamin Type A / genetics*
  • Models, Genetic
  • Mutation*
  • Progeria / genetics*
  • Telomere / genetics

Substances

  • Lamin Type A