Anthocyanins from Eugenia brasiliensis edible fruits as potential therapeutics for COPD treatment

Food Chem. 2012 Oct 1;134(3):1256-62. doi: 10.1016/j.foodchem.2012.01.086. Epub 2012 Feb 18.

Abstract

Nine anthocyanins (1-9) from the edible fruits of Eugenia brasiliensis were identified by HPLC-PDA and LC-MS, and seven of these are described for the first time in this Brazilian fruit. Two of the major anthocyanins, delphinidin (8) and cyanidin (9), were studied for their inhibitory activity against chemokine interleukin-8 (IL-8) production before and after cigarette smoke extract (CSE) treatment of cells. In non-treated cells the amount of IL-8 was unchanged following treatment with cyanidin and delphinidin in concentrations 0.1-10 μM. Both delphinidin (8) and cyanidin (9) decreased the production of IL-8 in treated cells, at 1 and 10 μM, respectively. Delphinidin (8) demonstrated IL-8 inhibition in the CSE treated cells in a dose-dependent manner.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anthocyanins / pharmacology*
  • Brazil
  • Cells, Cultured
  • Chromatography, High Pressure Liquid
  • Epithelial Cells / drug effects
  • Epithelial Cells / metabolism
  • Eugenia / chemistry*
  • Fruit / chemistry*
  • Humans
  • Interleukin-8 / metabolism*
  • Mass Spectrometry
  • Plant Extracts / pharmacology*
  • Pulmonary Disease, Chronic Obstructive / drug therapy*
  • Respiratory System / drug effects
  • Respiratory System / metabolism
  • Smoke / adverse effects

Substances

  • Anthocyanins
  • Interleukin-8
  • Plant Extracts
  • Smoke