Piper species protect cardiac, hepatic and renal antioxidant status of atherogenic diet fed hamsters

Food Chem. 2012 Oct 1;134(3):1354-9. doi: 10.1016/j.foodchem.2012.03.030. Epub 2012 Mar 23.


Pre-clinical and clinical studies points to the use of antioxidants as an effective measure to reduce the progression of oxidative stress related disorders. The present study evaluate the effect of three Piper species (Piper guineense, Piper nigrum and Piper umbellatum) for the protection of cardiac, hepatic and renal antioxidant status of atherogenic diet fed hamsters. Hamsters were classified into eight groups: a normal control, atherogenic control and six other experimental groups (fed atherogenic diet supplemented with different doses of P. nigrum, P. guineense and P. umbellatum (1 and 0.25 g/kg) for 12 weeks. At the end of the feeding period the heart, liver and kidney from each group were analyzed for lipid profile and antioxidant enzymes activities. Atherogenic diet induced a significant (P<0.001) increase in the lipid profile across the board and equally significantly altered the antioxidant enzyme activities. Supplementation with Piper species significantly inhibited the alteration effect of atherogenic diet on the lipid profile and antioxidant enzymes activities. The Piper extracts may possess an antioxidant protective role against atherogenic diet induced oxidative stress in cardiac, hepatic and renal tissues.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Antioxidants / metabolism*
  • Atherosclerosis / chemically induced
  • Atherosclerosis / drug therapy*
  • Cricetinae
  • Diet, Atherogenic / adverse effects*
  • Heart / drug effects*
  • Kidney / drug effects*
  • Lipids / analysis
  • Liver / drug effects*
  • Liver / metabolism
  • Male
  • Oxidation-Reduction
  • Oxidative Stress / drug effects
  • Piper / chemistry*
  • Plant Extracts / pharmacology*


  • Antioxidants
  • Lipids
  • Plant Extracts