The tumour microenvironment in B cell lymphomas

Nat Rev Cancer. 2014 Aug;14(8):517-34. doi: 10.1038/nrc3774. Epub 2014 Jul 10.


B cell lymphomas are cancers that arise from cells that depend on numerous highly orchestrated interactions with immune and stromal cells in the course of normal development. Despite the recent focus on dissecting the genetic aberrations within cancer cells, it has been increasingly recognized that tumour cells retain a range of dependence on interactions with the non-malignant cells and stromal elements that constitute the tumour microenvironment. A fundamental understanding of these interactions gives insight into the pathogenesis of most B cell lymphomas and, moreover, identifies novel therapeutic opportunities for targeting oncogenic pathways, both now and in the future.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Humans
  • Lymphoma, B-Cell / etiology
  • Lymphoma, B-Cell / mortality
  • Lymphoma, B-Cell / pathology*
  • Lymphoma, B-Cell / therapy
  • Prognosis
  • Tumor Escape
  • Tumor Microenvironment* / drug effects
  • Tumor Microenvironment* / genetics
  • Tumor Microenvironment* / immunology