Cu-catalyzed arylcarbocyclization of alkynes with diaryliodonium salts through C-C bond formation on inert C(sp3)-H bond

Jing Peng; Chao Chen; Junjie Chen; Xiang Su; Chanjuan Xi; Hui Chen

doi:10.1021/ol501655g

Cu-catalyzed arylcarbocyclization of alkynes with diaryliodonium salts through C-C bond formation on inert C(sp3)-H bond

Org Lett. 2014 Jul 18;16(14):3776-9. doi: 10.1021/ol501655g. Epub 2014 Jul 10.

Authors

Jing Peng¹, Chao Chen, Junjie Chen, Xiang Su, Chanjuan Xi, Hui Chen

Affiliation

¹ Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University , Beijing 100084, China.

PMID: 25008539
DOI: 10.1021/ol501655g

Abstract

Copper-catalyzed arylcarbocyclization reaction of alkynes was realized with diaryliodonium salts through C-C bond formation on an inert C(sp3)-H bond. This method provides an efficient cyclization of alkyl alkynes to generate carbocycles with good step-economy. Theoretical study revealed an interesting Cu-catalyzed concerted pathway of the C-C bond formation.

Publication types

Research Support, Non-U.S. Gov't