The carbonic anhydrases: widening perspectives on their evolution, expression and function

Bioessays. 1989 Jun;10(6):186-92. doi: 10.1002/bies.950100603.


Now, some 55 years after its discovery in bovine red cells, carbonic anhydrase (CA), in all its varied forms, continues to challenge and intrigue physiologists, biochemists and molecular geneticists. This is so because of an increasing awareness of the many apparently diverse functions of the different CA isozymes encoded by this large multigene family, the continuing discovery of new CA, or CA-related, genes, and the extensive variation in their hormonal control, cellular expression and subcellular localization.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Biological Evolution*
  • Carbonic Anhydrases / genetics*
  • Carbonic Anhydrases / metabolism
  • Genes
  • Humans
  • Molecular Sequence Data
  • Protein Conformation
  • Sequence Homology, Nucleic Acid


  • Carbonic Anhydrases