Health related quality of life in people with advanced chronic liver disease

J Hepatol. 2014 Nov;61(5):1158-65. doi: 10.1016/j.jhep.2014.06.034. Epub 2014 Jul 7.


Cirrhosis has a long natural history with considerable symptomatic impacts, particularly in advancing disease. Measuring health related quality of life (HRQOL) in liver disease provides detail about the nature and extent of its effects on individuals. Understanding the drivers of impaired HRQOL can help identify targets for improvement through new treatments or health systems service delivery. Evaluation of novel therapies which target symptomatic improvement, should be done with suitable outcome measures, including HRQOL assessment. In this article, we provide an overview of HRQOL in advanced liver disease for the clinician. A clear description of the important HRQOL tools is given alongside a discussion of the factors, which are known to contribute to impaired HRQOL in advanced liver disease.

Keywords: Cirrhosis; Health related quality of life; Liver; Quality of life.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Ascites
  • Chronic Disease
  • Hepatic Encephalopathy
  • Humans
  • Liver Cirrhosis
  • Liver Diseases* / etiology
  • Quality of Life*
  • Severity of Illness Index
  • Surveys and Questionnaires