Chronic L-deprenyl-induced up-regulation of the dopamine uptake carrier

Eur J Pharmacol. 1989 Apr 12;163(1):191-4. doi: 10.1016/0014-2999(89)90418-4.

Abstract

L-Deprenyl is an inhibitor of monoamine oxidase B and dopamine uptake. Chronic L-deprenyl (10 mg/kg i.p., twice weekly for 4 weeks) was shown to inhibit monoamine oxidase B activity by 89%, and also to induce an up-regulation of the [3H]mazindol binding site associated with the striatal dopamine uptake carrier. Scatchard analysis indicated a 56% increase in the maximal number of [3H]mazindol binding sites in chronic L-deprenyl animals, but no effect on the affinity of these binding sites. The ability of L-deprenyl to up-regulate the [3H]mazindol-associated dopamine uptake carrier appears to be a result of its role as a dopamine uptake inhibitor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3,4-Dihydroxyphenylacetic Acid / metabolism
  • Animals
  • Catecholamines / metabolism
  • Corpus Striatum / drug effects
  • Corpus Striatum / metabolism
  • Dopamine / analogs & derivatives
  • Dopamine / metabolism
  • Dopamine / pharmacology
  • Male
  • Mazindol / pharmacology
  • Mice
  • Mice, Inbred BALB C
  • Monoamine Oxidase / metabolism
  • Phenethylamines / pharmacology*
  • Receptors, Dopamine / drug effects*
  • Selegiline / pharmacology*

Substances

  • Catecholamines
  • Phenethylamines
  • Receptors, Dopamine
  • 3,4-Dihydroxyphenylacetic Acid
  • Selegiline
  • Mazindol
  • Monoamine Oxidase
  • 3-methoxytyramine
  • Dopamine