[Mechanisms of actoprotective action of succinic acid's derivatives]

Lik Sprava. 2013 Apr-May;(3):78-85.
[Article in Ukrainian]

Abstract

Research on establishment of mechanisms of metabolitotropic compounds' actoprotective action--derivatives of succinic acid yakton and mexidol, based on the definition of their antihypoxic, antioxidant, mitoprotective, and ergogenic properties are presented in this article. In case of hypoxic, haemic, and circulatory hypoxia yakton and mexidol influence on parameters of prooxidant-antioxidant homeostasis, as well as prevent disturbances of glycolysis, content of macroergic compounds, changes of RNA-content in nerve tissue, and development of mitochondrial dysfunction. Yakton's actoprotective effect based on enhancement of adenine nucleotides' content in liver, myocardium, and skeletal muscles is also established with high-speed loading, as well as using preliminary cooling or hyperthermia. Wide range of yakton's effects (antihypoxic, membraneprotective, cardioprotective, etc.) is also confirmed according to the data of quantum-chemical research.

MeSH terms

  • Adenine Nucleotides / metabolism
  • Animals
  • Benzimidazoles / pharmacology*
  • Benzimidazoles / therapeutic use
  • Energy Metabolism / drug effects
  • Female
  • Fever / drug therapy
  • Fever / metabolism
  • Homeostasis / drug effects
  • Hypothermia / drug therapy
  • Hypothermia / metabolism
  • Hypoxia / drug therapy
  • Hypoxia / metabolism
  • Male
  • Organ Specificity
  • Picolines / pharmacology*
  • Picolines / therapeutic use
  • Rats
  • Rats, Wistar
  • Succinates / pharmacology*
  • Succinates / therapeutic use

Substances

  • Adenine Nucleotides
  • Benzimidazoles
  • Picolines
  • Succinates
  • yakton
  • emoxypine succinate